Emtricitabine-Tenofovir Concentrations and Pre-Exposure Prophylaxis Efficacy in
نویسنده
چکیده
tablets is a robust intervention for preventing HIV acquisition among men who have sex with men. 99% for two, four, and seven doses per week, respectively. These findings suggest that PrEP using oral FTC-TDF model was used to analyze the STRAND TFV-DP concentrations, the predicted HIV risk reductions were 76, 96, and PBMCs (31 to 47) after seven doses per week. When the iPrEx study's regression 6 doses per week, and 42 fmol/10 PBMCs (25 to 39) after four 6 PBMCs (6 to 13) after two doses per week, 32 fmol/10 6 concentration of 11 fmol/10 was detected in the blood at all dosing levels in all participants with a median (interquartile range) TFV-DP concentrations from another study called STRAND were used to establish expected TFV-DP concentrations. TFV-DP placebo in the iPrEx study. To determine the number of tablets required to achieve this drug concentration, TFV-DP (PBMCs) (95% confidence interval, 3 to 28) was associated with a 90% reduction in HIV acquisition relative to peripheral blood mononuclear cells 6 regression analysis predicted that a TFV-DP concentration of 16 fmol/10 drug concentrations and adherence levels associated with protection from HIV-1 acquisition in the iPrEx trial. A estimates specific et al. powerful determinant of drug efficacy at preventing HIV acquisition. A new study by Anderson risk was reduced by more than 90% among those having detectable drug in blood, indicating that adherence was a of HIV prevention services. HIV infections were reduced by 44% overall in the FTC-TDF arm relative to placebo. HIV FTC-TDF as PrEP in HIV-negative men who have sex with men. Participants all received a comprehensive package and tenofovir-diphosphate (TFV-DP). The iPrEx study was a randomized placebo-controlled trial of daily oral doses of mononuclear cells to the pharmacologically active triphosphate moieties, called emtricitabine-triphosphate (FTC-TP) fumarate (TDF) is a recently proven strategy for preventing HIV acquisition. These drugs require phosphorylation in Pre-exposure prophylaxis (PrEP) using the antiretroviral drugs emtricitabine (FTC) and tenofovir disoproxil PrEParing to Stop HIV Acquisition
منابع مشابه
Pre-exposure Prophylaxis for the Prevention of HIV Transmission to Women in the United States
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تاریخ انتشار 2012